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《环境科学与工程前沿(英文)》 2023年 第17卷 第3期 doi: 10.1007/s11783-023-1628-x
● Metabolome can distinguish pregnant women exposure to PFOA at different degrees.
关键词: Perfluorooctanoic acid Exposure Pregnant women Metabolomic GSH Microbiota metabolism
Recent advances in systemic lupus erythematosus and microbiota: from bench to bedside
《医学前沿(英文)》 2022年 第16卷 第5期 页码 686-700 doi: 10.1007/s11684-022-0957-7
Proteins moonlighting in tumor metabolism and epigenetics
Lei Lv, Qunying Lei
《医学前沿(英文)》 2021年 第15卷 第3期 页码 383-403 doi: 10.1007/s11684-020-0818-1
Gut microbiota and its implications in small bowel transplantation
null
《医学前沿(英文)》 2018年 第12卷 第3期 页码 239-248 doi: 10.1007/s11684-018-0617-0
The gut microbiota is mainly composed of a diverse population of commensal bacterial species and plays a pivotal role in the maintenance of intestinal homeostasis, immune modulation and metabolism. The influence of the gut microbiota on solid organ transplantation has recently been recognized. In fact, several studies indicated that acute and chronic allograft rejection in small bowel transplantation (SBT) is closely associated with the alterations in microbial patterns in the gut. In this review, we focused on the recent findings regarding alterations in the microbiota following SBT and the potential roles of these alterations in the development of acute and chronic allograft rejection. We also reviewed important advances with respect to the interplays between the microbiota and host immune systems in SBT. Furthermore, we explored the potential of the gut microbiota as a microbial marker and/or therapeutic target for the predication and intervention of allograft rejection and chronic dysfunction. Given that current research on the gut microbiota has become increasingly sophisticated and comprehensive, large cohort studies employing metagenomic analysis and multivariate linkage should be designed for the characterization of host–microbe interaction and causality between microbiota alterations and clinical outcomes in SBT. The findings are expected to provide valuable insights into the role of gut microbiota in the development of allograft rejection and other transplant-related complications and introduce novel therapeutic targets and treatment approaches in clinical practice.
关键词: gut microbiota small bowel transplantation acute rejection chronic rejection mucosal immunity biomarker microbiota-targeted therapy
肠道菌群调控的色氨酸代谢改善了D-Gal/LPS诱导的C57BL/6小鼠急性肝衰竭 Article
郑志鹏, 伍莉, 韩玉秋, 陈俊, 朱帅, 姚圆圆, 王保红, 李兰娟
《工程(英文)》 2022年 第14卷 第7期 页码 134-146 doi: 10.1016/j.eng.2020.12.013
急性肝衰竭(acute liver failure, ALF)发病突然,常常导致死亡。既往动物实验发现,口服益生菌或抗生素都可以减轻药物引起的肝损伤,提示肠道菌群在药物性肝损伤的病理生理过程中发挥着重要作用。然而,其潜在的作用机制尚不完全清楚。本研究旨在通过多组学的方法,研究肠道菌群在ALF中的综合作用。广谱抗生素(broad-spectrum antibiotics, Abx)灌胃4周,明显改善了D-盐酸半乳糖胺/脂多糖[D-(+)-galactosamine hydrochloride/lipopolysaccharide, D-Gal/LPS]诱导的 ALF 小鼠的生存期。RNA 测序显示,在Abx干预的ALF小鼠中,肝脏的炎症反应受到抑制,而整体代谢途径上调。肠道菌群16S rRNA测序发现,Abx重塑了肠道菌群的结构和功能,伴随肠道菌群的色氨酸(tryptophan, Trp)代谢通路增强。此外,经超高效液相色谱串联质谱(ultraperformance liquid chromatography-mass spectrometry, UPLC‒MS)代谢谱检测提示,Abx 干预肠道菌群后,减少了 Trp 的排泄,释放了更多的 Trp 予宿主,犬尿氨酸(kynurenine, Kyn)水平升高,Kyn通路增强。Kyn作为一种内源性芳香烃受体(aryl hydrocarbon receptor, AhR)的配体, 可以通过结合AhR发挥抗炎和免疫抑制的作用。此外,AhR靶向干预了影响了经Abx预处理或未经Abx预处理的ALF小鼠的预后,表明AhR通路在一定程度上调节了机体对ALF的易感性。本研究表明,依赖肠道菌群调控的色氨酸代谢可以通过调节AhR的活性,影响宿主对ALF的易感性,为更好地管理ALF提供了一个有前景的靶点。
ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis
《医学前沿(英文)》 页码 972-992 doi: 10.1007/s11684-023-0990-1
关键词: inflammatory bowel disease ADT-OH intestinal permeability gut microbiota
Vanadium metabolism investigation using substance flow and scenario analysis
Fangfang ZHANG, Huiquan LI, Bo CHEN, Xue GUAN, Yi ZHANG
《环境科学与工程前沿(英文)》 2014年 第8卷 第2期 页码 256-266 doi: 10.1007/s11783-013-0585-1
关键词: metabolism vanadium industry substance flow analysis scenario analysis
Insulin resistance and the metabolism of branched-chain amino acids
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 53-59 doi: 10.1007/s11684-013-0255-5
Insulin resistance (IR) is a key pathological feature of metabolic syndrome and subsequently causes serious health problems with an increased risk of several common metabolic disorders. IR related metabolic disturbance is not restricted to carbohydrates but impacts global metabolic network. Branched-chain amino acids (BCAAs), namely valine, leucine and isoleucine, are among the nine essential amino acids, accounting for 35% of the essential amino acids in muscle proteins and 40% of the preformed amino acids required by mammals. The BCAAs are particularly responsive to the inhibitory insulin action on amino acid release by skeletal muscle and their metabolism is profoundly altered in insulin resistant conditions and/or insulin deficiency. Although increased circulating BCAA concentration in insulin resistant conditions has been noted for many years and BCAAs have been reported to be involved in the regulation of glucose homeostasis and body weight, it is only recently that BCAAs are found to be closely associated with IR. This review will focus on the recent findings on BCAAs from both epidemic and mechanistic studies.
关键词: branched-chain amino acids leucine isoleucine valine insulin resistance
Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu
《医学前沿(英文)》 2021年 第15卷 第5期 页码 649-656 doi: 10.1007/s11684-021-0830-0
Altered intestinal microbiota associated with colorectal cancer
Hong Zhang, Ying Chang, Qingqing Zheng, Rong Zhang, Cheng Hu, Weiping Jia
《医学前沿(英文)》 2019年 第13卷 第4期 页码 461-470 doi: 10.1007/s11684-019-0695-7
关键词: colorectal cancer (CRC) gut microbiota intestinal Eubacterium Devosia
鱼类肠道菌群研究进展及潜在应用 Review
栾银银, 黎明, 周伟, 药园园, 杨雅麟, 张震, Einar Ringø, Rolf Erik Olsen, Jihong Liu Clarke, 解绶启, 麦康森, 冉超, 周志刚
《工程(英文)》 2023年 第29卷 第10期 页码 137-146 doi: 10.1016/j.eng.2022.12.011
肠道菌群在宿主健康和疾病中起着重要作用。我们对鱼类菌群的理解远落后于人类和其他哺乳动物。尽管如此,现有研究也强调了微生物对鱼类的健康、生长性能和各种生理功能中的重要性。目前,模式动物、经济鱼类和野生鱼类中都展开了微生物的研究。鱼类菌群的组成取决于宿主选择、饮食和环境等因素。肠道菌群可以影响鱼类宿主的营养代谢、免疫和抗病能力,而宿主则通过免疫和非免疫因素以鱼菌互作的方式调节肠道菌群的稳态。目前已经开发出的无菌鱼类模型,对于研究鱼类与微生物互作的机理研究有着重要意义。在本篇综述中,我们讨论了鱼类微生物研究的最新进展,描述了包括鱼类微生物多样性,以及宿主-菌群交互作用的研究结果。同时,还讨论了鱼类菌群对鱼类健康及行业可持续发展的潜在作用。
Dawen Gao, Xiaolong Wang, Hong Liang, Qihang Wei, Yuan Dou, Longwei Li
《环境科学与工程前沿(英文)》 2018年 第12卷 第3期 doi: 10.1007/s11783-018-1035-x
关键词: Anammox Metabolism Metagenome Ecological distribution Microbial interactions
Metabolism and immunity in breast cancer
Deyu Zhang, Xiaojie Xu, Qinong Ye
《医学前沿(英文)》 2021年 第15卷 第2期 页码 178-207 doi: 10.1007/s11684-020-0793-6
Weihua ZENG,Bo WU,Ying CHAI
《环境科学与工程前沿(英文)》 2016年 第10卷 第1期 页码 114-128 doi: 10.1007/s11783-014-0669-6
关键词: urban water metabolism system (UWMS) system dynamic simulation water environmental carrying capacity (WECC) feedback loops bilateral control
《医学前沿(英文)》 2022年 第16卷 第3期 页码 389-402 doi: 10.1007/s11684-021-0856-3
关键词: severe community-acquired pneumonia lung microbiota clinical improvements 7-category ordinal scale Prevotellaceae
标题 作者 时间 类型 操作
Untargeted metabolomic analysis of pregnant women exposure to perfluorooctanoic acid at different degrees
期刊论文
ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis
期刊论文
Vanadium metabolism investigation using substance flow and scenario analysis
Fangfang ZHANG, Huiquan LI, Bo CHEN, Xue GUAN, Yi ZHANG
期刊论文
Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship
Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu
期刊论文
Altered intestinal microbiota associated with colorectal cancer
Hong Zhang, Ying Chang, Qingqing Zheng, Rong Zhang, Cheng Hu, Weiping Jia
期刊论文
鱼类肠道菌群研究进展及潜在应用
栾银银, 黎明, 周伟, 药园园, 杨雅麟, 张震, Einar Ringø, Rolf Erik Olsen, Jihong Liu Clarke, 解绶启, 麦康森, 冉超, 周志刚
期刊论文
Anaerobic ammonia oxidizing bacteria: ecological distribution, metabolism, and microbial interactions
Dawen Gao, Xiaolong Wang, Hong Liang, Qihang Wei, Yuan Dou, Longwei Li
期刊论文
Dynamic simulation of urban water metabolism under water environmental carrying capacity restrictions
Weihua ZENG,Bo WU,Ying CHAI
期刊论文